Explore new therapeutic, diagnostic, cell, and gene technology research with original sources.
The study presents a process for rapidly testing the effectiveness of personalized nucleic acid therapies in heart organoids derived from patient cells.
Published 2025.01.22View evidence and readiness →The study demonstrates scalable production of human cortical organoids using a biocompatible polymer to reduce aggregation.
Published 2025.06.27View evidence and readiness →The study systematically identified gene edits that enhance the cancer-fighting ability and survival of CAR-T cells.
Published 2025.09.24View evidence and readiness →This study develops and validates a new inflammation-related biomarker called ANLR that combines albumin levels with the neutrophil-to-lymphocyte ratio to predict cancer patient outcomes.
Published 2026-10-07View evidence and readiness →A machine learning-based Treg-related gene signature was developed to predict clinical outcomes and immunotherapy benefits in skin cutaneous melanoma.
Published 2026-10-06View evidence and readiness →This study presents a compact 13-level switched-capacitor inverter that uses 11 switches, 2 capacitors, and 2 diodes to achieve 13 symmetrical output levels with high efficiency and intrinsic capacitor self-balancing.
Published 2026-10-06View evidence and readiness →The study presents a novel method using 2D nanomaterials and machine learning to develop flexible, sensitive biosensors for health monitoring.
Published 2026-10-05View evidence and readiness →This study evaluated the effect of temporarily stopping biologic or targeted synthetic DMARD therapy on the immune response to a COVID-19 supplemental dose vaccine and on disease activity in patients with inflammatory arthritis.
Published 2026-10-05View evidence and readiness →This study demonstrates a single-laser scheme for achieving strong-field quantum electrodynamics (QED) effects through direct laser acceleration of electrons and their collision with a reflected laser pulse.
Published 2026-10-05View evidence and readiness →This systematic review evaluates the learning curve for robotic-assisted microsurgery, showing that anastomosis time decreases with practice, though robot-assisted techniques remain slower than hand-sewn methods.
Published 2026-10-05View evidence and readiness →This study evaluated the safety and effectiveness of ibrutinib in Indian patients with chronic lymphocytic leukemia and mantle cell lymphoma under controlled conditions.
Published 2026-10-05View evidence and readiness →This study identifies and engineers avian R2 retrotransposons for all-RNA-mediated targeted DNA integration in human cells, achieving up to 60% site-specific gene integration.
Published 2026-10-05View evidence and readiness →This study evaluated the effectiveness of sound therapy in adults with chronic bilateral tinnitus and mild hearing loss through a multicenter, double-blind, placebo-controlled trial.
Published 2026-10-05View evidence and readiness →A case report shows that olaparib treatment improved liver function in a patient with metastatic BRCA1-mutated breast cancer, suggesting potential metabolic benefits of PARP inhibitors in liver steatosis.
Published 2026-10-05View evidence and readiness →This study investigated the prognostic role of CCT5 in breast cancer and its mechanism in promoting tumor growth, showing that CCT5 affects cancer progression by modulating the p53 pathway.
Published 2026-10-05View evidence and readiness →This study presents real-world outcomes from the first newborn screening pilots for metachromatic leukodystrophy, showing how early detection and treatment can be implemented in clinical practice.
Published 2026-10-04View evidence and readiness →This study evaluates the cost-effectiveness of a one-time gene therapy for haemophilia B compared to standard prophylactic treatment in Swedish adults.
Published 2026-10-04View evidence and readiness →This study evaluates advanced machine learning strategies for predicting therapy response in preclinical glioblastoma using longitudinal MRI data, comparing radiomic and deep learning approaches.
Published 2026-10-04View evidence and readiness →A phase I trial tested a CCL21 gene-modified dendritic cell vaccine combined with pembrolizumab in advanced non-small cell lung cancer patients, but the treatment did not achieve the expected objective response rate.
Published 2026-10-04View evidence and readiness →This study assessed the feasibility, safety, and acceptability of the Knee-LOCOBOT, a robotic rehabilitation device for knee osteoarthritis, but did not evaluate its effectiveness due to lack of control, randomization, or blinding.
Published 2026-10-04View evidence and readiness →This study uses Arrhenius kinetics and Total Acid Number (TAN) analysis to model the degradation of triglyceride-based hydraulic fluids under extreme thermal stress, showing that TAN is a more sensitive indicator of chemical breakdown than traditional physical parameters like viscosity.
Published 2026-10-03View evidence and readiness →This paper discusses ethical challenges in conducting clinical trials for rare neurological and neurodevelopmental disorders, focusing on issues like equipoise, placebo use, informed consent, and equitable access.
Published 2026-10-03View evidence and readiness →This study demonstrates that co-doping Y3(Al,Ga)5O12:Ce with Mg2+ and adjusting Ga content enhances Ce4+ stabilization and improves scintillation efficiency through Ce3+ to Ce4+ conversion.
Published 2026-10-03View evidence and readiness →This study updates the Oracle horizon-scanning model to estimate Italian National Healthcare Service expenditure on multiple sclerosis disease-modifying therapies from 2025 to 2029.
Published 2026-10-03View evidence and readiness →A combination of photothermal therapy and a tumor-targeted interferon immunocytokine with immune checkpoint blockade was shown to create a durable abscopal effect by reprogramming the tumor microenvironment and enhancing immune memory.
Published 2026-10-03View evidence and readiness →This study compares self-managed and professionally managed construction projects using AHP to identify optimal management practices in developing countries.
Published 2026-10-03View evidence and readiness →This study compared the quality, readability, and response length of AI-generated answers to patient-oriented questions about Peyronie’s disease using four large language models.
Published 2026-10-03View evidence and readiness →This study uses computational modeling to determine the minimum size of an O RhD-negative hiPSC-derived RBC clone bank needed to cover alloimmunized patients in a Saudi population, based on real-world antibody frequency data and antigen-negativity constraints.
Published 2026-10-03View evidence and readiness →The study evaluated the long-term efficacy and safety of ibrutinib-venetoclax versus chlorambucil-obinutuzumab in older patients with chronic lymphocytic leukemia, showing better outcomes with ibrutinib-venetoclax.
Published 2026-10-02View evidence and readiness →This study investigates the Genomic Instability Score (GIS) as a potential biomarker for guiding platinum-based treatment decisions in advanced pancreatic ductal adenocarcinoma, beyond traditional single-gene testing for homologous recombination deficiency (HRD).
Published 2026-10-02View evidence and readiness →This paper extends Regulated Trinary Reduction Theory (RTRT) to analyze anomalous physics and the historical development of unconventional research in gravity, time, and propulsion.
Published 2026-10-02View evidence and readiness →This study demonstrates that focused ultrasound increases the transport of Lucifer Yellow across human cerebral microvascular endothelial monolayers without microbubbles.
Published 2026-10-02View evidence and readiness →This study analyzed the treatment patterns and guideline adherence for non-muscle-invasive bladder cancer in three Mexican hospitals during BCG shortages, highlighting clinical characteristics and management approaches.
Published 2026-10-02View evidence and readiness →This study evaluated the cost-effectiveness of ribociclib plus an aromatase inhibitor compared to aromatase inhibitor alone and tamoxifen from a Canadian public payer perspective for early breast cancer treatment.
Published 2026-10-02View evidence and readiness →A two-step membrane chromatography process was developed for efficient plasmid DNA purification, combining capture and polishing in an integrated system.
Published 2026-10-02View evidence and readiness →This study evaluated the appropriateness of radiotherapy intensity selection based on patient-reported outcomes and oncologists' experience in older cancer patients.
Published 2026-10-02View evidence and readiness →This study used interpretable machine learning to identify health system factors that influence prostate cancer survival outcomes at the country level.
Published 2026-10-02View evidence and readiness →A randomized trial found that dual antiretroviral therapy with dolutegravir and lamivudine achieves similar viral suppression in peripheral blood as triple therapy, with evidence of lymph node reservoir reduction.
Published 2026-10-02View evidence and readiness →The study presents a noninvasive liquid biopsy method using urine cell-free RNA for detecting bladder cancer and predicting treatment response, showing high sensitivity and specificity.
Published 2026-10-02View evidence and readiness →The study developed nomograms integrating clinical data, ADC values, and MRI radiomics to predict treatment outcomes and explore the biological basis in LACC patients after CCRT.
Published 2026-10-02View evidence and readiness →This study developed an mRNA-LNP system with m6A modifications to enable in vivo CAR expression and demonstrate its potential to induce antitumor immune responses.
Published 2026-10-02View evidence and readiness →The study analyzed the transcriptome of s-SHIP-expressing breast cancer cells and identified PIERCE1 as a novel gene linked to drug resistance in these cells.
Published 2026-10-02View evidence and readiness →This study evaluated a machine learning-based record linkage method for Brazilian health databases and compared it with an existing probabilistic linkage tool.
Published 2026-10-02View evidence and readiness →RESTOR generates test oracles for RESTful APIs using reinforcement learning from a single request-response pair, avoiding reliance on formal specifications or historical logs.
Published 2026-10-01View evidence and readiness →This study investigated the mediating role of fear of progression between symptom burden and social alienation in lung cancer patients undergoing chemotherapy.
Published 2026-10-01View evidence and readiness →This study evaluated how bridging therapy and disease type affect outcomes in patients with relapsed/refractory multiple myeloma treated with cilta-cel.
Published 2026-10-01View evidence and readiness →A phase I trial evaluated the safety and preliminary efficacy of a carbon nanoparticle-Fe (II) complex (CNSI-Fe) for inducing ferroptosis in refractory solid tumors.
Published 2026-10-01View evidence and readiness →The study demonstrates that METTL3-mediated m⁶A methylation of E2F2 stabilizes E2F2 mRNA, leading to increased MCU expression and promoting gastric cancer cell malignancy.
Published 2026-10-01View evidence and readiness →This Clinical Outlook reviews recent advances in p53-targeted therapies for TP53-mutated cancers.
Published 2026-10-01View evidence and readiness →A structured nutrition-centred multidisciplinary supportive-care program was associated with improved treatment tolerance and clinical outcomes in patients undergoing precision radiotherapy for head and neck cancer.
Published 2026-10-01View evidence and readiness →This study evaluated the attitudes of respiratory therapy students in Saudi Arabia toward patient safety using the Safety Attitudes Questionnaire and identified factors associated with positive safety attitudes.
Published 2026-10-01View evidence and readiness →This study establishes a patient-derived teratoma model to evaluate ex vivo and in vivo strategies for restoring dystrophin in Duchenne muscular dystrophy, demonstrating partial restoration of shorter dystrophin isoforms through cell therapy and base editing.
Published 2026-10-01View evidence and readiness →This study analyzed real-world data on the use of adjuvant olaparib in HER2-negative early-stage breast cancer patients, focusing on treatment patterns, persistence, adherence, and combination strategies.
Published 2026-09-30View evidence and readiness →This paper systematizes and analyzes Nikolai Ivanovich Volkov's mathematical models of energy metabolism adaptation to physical loads, highlighting his pioneering work in sport bioenergetics.
Published 2026-09-30View evidence and readiness →This paper presents a hybrid forecasting model that combines linear and nonlinear approaches to improve community net load prediction under high distributed generation penetration.
Published 2026-09-30View evidence and readiness →This scoping review examines the role of quantitative dosage in speech therapy for children with phonological impairment, suggesting that more intensive approaches may be more effective.
Published 2026-09-30View evidence and readiness →This study uses a two-part model to estimate healthcare costs associated with different oral anticoagulant treatment patterns in patients with atrial fibrillation, highlighting socioeconomic disparities.
Published 2026-09-30View evidence and readiness →This paper discusses how artificial intelligence is transforming drug design and development through various applications like target identification, virtual screening, and molecular design.
Published 2026-09-30View evidence and readiness →This multicenter retrospective study analyzed treatment patterns and clinical outcomes in Chinese patients with newly diagnosed multiple myeloma, focusing on high-risk subgroups such as elderly patients, those with renal impairment, and those with 1q cytogenetic abnormalities.
Published 2026-09-30View evidence and readiness →This study analyzed real-world treatment patterns for patients with 3L+ DLBCL using a multiple index date qualification methodology to compare with clinical trial data.
Published 2026-09-30View evidence and readiness →This study evaluated patient-reported outcomes 1 year after conjunctival melanoma treatment using the EORTC QLQ-C30 and QLQ-OPT30 questionnaires to assess health, symptoms, and quality of life.
Published 2026-09-30View evidence and readiness →The study demonstrates the use of cord blood- or peripheral blood-derived endothelial colony-forming cells to create vascularized artificial tissues that form stable vascular structures after transplantation.
Published 2026-09-30View evidence and readiness →The study presents a population-scale immune multiome atlas that links genetic variants to disease through integrated analysis of chromatin accessibility and gene expression.
Published 2026-09-30View evidence and readiness →This study evaluates the clinical relevance of 46 prostate cancer cell lines using an integrated multiomics approach and clinical data from over 10,000 patient cases across multiple countries.
Published 2026-09-30View evidence and readiness →This study evaluated the long-term safety and nutritional adequacy of dehulled faba bean ingredients in adult dogs, finding similar body composition, serum biochemistry, plasma amino acids, and cardiac function compared to a corn-based diet after 26 weeks.
Published 2026-09-29View evidence and readiness →This expert review examines the gastrointestinal side effects of GLP-1 receptor agonists and dual GIP/GLP-1 receptor agonists, focusing on their incidence, mechanisms, and management in diabetes and obesity treatments.
Published 2026-09-29View evidence and readiness →This review discusses how quantitative medicine and model-informed drug development can improve decision-making in oncology drug development by integrating pharmacology, disease biology, clinical data, biomarkers, and computational modeling.
Published 2026-09-29View evidence and readiness →DentalGEN is a large-scale generative AI framework that designs patient-specific dental crowns by integrating morphological, functional, and aesthetic criteria through a multi-view diffusion model with explicit control mechanisms.
Published 2026-09-29View evidence and readiness →This study evaluated the effectiveness of tucatinib, trastuzumab, and capecitabine as a treatment after trastuzumab deruxtecan in HER2-positive metastatic breast cancer.
Published 2026-09-29View evidence and readiness →This study reviews the roles of RNA-binding proteins (RBPs) in cellular processes and their connections to disease, with a focus on their potential as therapeutic targets and biomarkers, including newly identified cell surface RBPs.
Published 2026-09-29View evidence and readiness →The study developed nomograms to predict 1-, 3-, and 5-year overall and cancer-specific survival for rare histological variant prostate cancer patients using clinicopathological data and statistical models.
Published 2026-09-29View evidence and readiness →This study found no significant association between cumulative operating time during CRRT and patient mortality, but identified an early transmembrane pressure surge as a potential predictor of mortality.
Published 2026-09-29View evidence and readiness →This study found that only 20% of young breast cancer patients in Ethiopia initiated all recommended multimodal treatment within one year, highlighting significant barriers to comprehensive cancer care.
Published 2026-09-29View evidence and readiness →This study presents an engineered exosome-based drug delivery system that encapsulates MDC and uses CeO₂@PDA nanozymes and PEG-γ3 peptides for targeted treatment of sepsis-induced acute lung injury.
Published 2026-09-29View evidence and readiness →This study expresses and characterizes IL-21 in E. coli and demonstrates its combined effect with IL-2 as a potential cancer therapy.
Published 2026-09-29View evidence and readiness →This study evaluated the effects of posterior open contacts on dental movement and skeletal stability in orthognathic surgery using 3D analysis.
Published 2026-09-29View evidence and readiness →This study uses CFD simulations to compare heat transfer and flow characteristics of three wall structures in heat-exchange pipes, finding that sharper surfaces increase turbulence and heat transfer efficiency.
Published 2026-09-28View evidence and readiness →This study proposes that FOXM1 functions as a regulatory switch integrating multiple biological processes, influencing cancer cell behavior and therapy resistance.
Published 2026-09-28View evidence and readiness →This study evaluated the use of plasma Aβ measurements in combination with p-tau217 to reduce diagnostic uncertainty in MCI patients.
Published 2026-09-28View evidence and readiness →This study estimates the budget impact of introducing subcutaneous IgPro20 pre-filled syringes for treating primary immunodeficiency, secondary immunodeficiency, and chronic inflammatory demyelinating polyneuropathy in Italy.
Published 2026-09-28View evidence and readiness →This study provides a detailed safety analysis of sacituzumab tirumotecan in patients with metastatic triple-negative breast cancer who have received prior treatment, focusing on adverse events such as hematologic toxicities and stomatitis.
Published 2026-09-28View evidence and readiness →This study developed a standardized algorithm for selecting patients for cellular therapy across 19 malignancies and 5 therapy types, with structured decision-making logic for complex clinical scenarios.
Published 2026-09-28View evidence and readiness →This study presents a framework for standardizing a human TBMNK cell assay across different flow cytometry platforms to improve reproducibility and AI readiness of cell therapy quality data.
Published 2026-09-28View evidence and readiness →